ArticleFrontiers in medicine2025
High serum unconjugated bilirubin levels following successful treatment of antiepileptic drug-induced bullosa epidermolysis: a case report and review of the literature.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Concurrent moxifloxacin-induced liver injury and toxic epidermal necrolysis after immune checkpoint inhibition: a case report and literature review.Frontiers in immunology · 2026Pooled it
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6 authors.
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Abstract
Most of the classical antiepileptic drugs (AEDs) such as lamotrigine (LTG) and levetiracetam (LEV) are known to potentially cause skin lesions and liver injury. This paper reports an unusual phenomenon that serum levels of unconjugated bilirubin (IBIL) abnormally increased after the successful treatment of AED-induced bullosa epidermolysis, regardless of the presence of genetic mutations associated with hepatocellular bilirubin metabolism. A 14-year-old female, who was suffering from epilepsy, presented to our hospital with fever and red papules all over her body. Based on histopathological examination of the skin biopsy specimen and a medical history of LTG and LEV use, toxic epidermal necrolysis (TEN) was confirmed. After methylprednisolone treatment for 29 days, the skin lesions showed retreated but drug-induced liver injury (DILI) aggravated. Serum biochemical test results revealed elevated levels of serum total bilirubin, conjugated bilirubin, IBIL, gamma glutamyl transpeptidase, alkaline phosphatase, total cholesterol, and total bile acid. B-ultrasound examination indicated cholecystitis. The upper abdominal magnetic resonance cholangiopancreatography was performed four times on her and revealed progressive dilatation of the biliary ducts and cholestasis. A whole-exon sequencing of the liver biopsy specimen revealed a heterozygous 1249G>A mutation in the
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