Evidence map›Paper›PMID 41113999›Full record

ArticleJHLT open2025

Clinical impact of an upfront RVAD strategy in HeartMate 3 LVAD recipients with severe early right ventricular failure requiring temporary mechanical support.

Marta Lorente-Ros, Mohammad S Husain, Miguel Pinilla-Vera, Richa Gupta, Rosaria S Prasad, Blanca Simon Frances, Jiling Chou, Ajay Kadakkal, Alexander I Papolos, Benjamin B Kenigsberg and 5 more

Abstract read
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marta Lorente-RosMedStar Heart and Vascular Institute, Washington, DC.
Mohammad S HusainMedStar Heart and Vascular Institute, Washington, DC.
Miguel Pinilla-VeraMedStar Heart and Vascular Institute, Washington, DC.
Richa GuptaMedStar Heart and Vascular Institute, Washington, DC.
Rosaria S PrasadMedStar Heart and Vascular Institute, Washington, DC.
Blanca Simon FrancesMedStar Heart and Vascular Institute, Washington, DC.
Jiling ChouMedStar Heart and Vascular Institute, Washington, DC.
Ajay KadakkalMedStar Heart and Vascular Institute, Washington, DC.
Alexander I PapolosMedStar Heart and Vascular Institute, Washington, DC.
Benjamin B KenigsbergMedStar Heart and Vascular Institute, Washington, DC.
Michael HocksteinMedStar Heart and Vascular Institute, Washington, DC.
Ezequiel J MolinaPiedmont Heart Institute, Atlanta, Georgia.
Keki BalsaraMedStar Heart and Vascular Institute, Washington, DC.
Farooq H SheikhMedStar Heart and Vascular Institute, Washington, DC.
Phillip H LamMedStar Heart and Vascular Institute, Washington, DC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Left ventricular assist device (LVAD) recipients are at risk of developing early right ventricular failure (RVF), at times necessitating temporary mechanical support with right ventricular assist device (RVAD). The optimal timing of RVAD implantation in these patients is unclear. The aim of this study is to compare clinical outcomes between upfront RVAD (U-RVAD) and rescue RVAD (R-RVAD) in LVAD recipients with early RVF. Methods: In this single-center retrospective cohort study, we included all patients who underwent HeartMate 3 (HM3) LVAD implant and required temporary RVAD for severe early RVF (30 days of LVAD implantation), from January 2019 to September 2024. U-RVAD was defined as RVAD use during the index LVAD operation. Baseline characteristics, perioperative outcomes, and mortality were compared between patients with U-RVAD and those with R-RVAD. Results: During the study period, 402 patients underwent HM3 LVAD implantation, of whom 64 received temporary RVAD for severe early RVF (mean age 57 years, 27% female). Thirty-six received U-RVAD. The incidence of perioperative atrial arrhythmia and renal replacement therapy was lower in patients who received U-RVAD compared to those who received R-RVAD ( Conclusions: In HM3 LVAD recipients with severe early RVF requiring RVAD, U-RVAD was associated with improved clinical outcomes.

Indexed as

advanced heart failureHeartMate 3 LVADrescue RVADright ventricular failureupfront RVAD

Identifiers

PMID41113999
PMCPMC12528927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.