Evidence map›Paper›PMID 41113981›Full record

ArticleAmerican journal of cancer research2025

Clinical benefits of laser therapy in von hippel-lindau syndrome: improved vision and reduced complications.

Lina Zhang, Wu Huang, Jun Li, Qinlin Liu, Lingli Feng, Qiuju Zhou

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Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Lina ZhangDepartment of Ophthalmology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
Wu HuangDepartment of Otorhinolaryngology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
Jun LiDepartment of Ophthalmology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
Qinlin LiuDepartment of Ophthalmology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
Lingli FengDepartment of Ophthalmology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
Qiuju ZhouDepartment of Ophthalmology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the long-term effectiveness of laser photocoagulation in treating retinal angiomas associated with von Hippel-Lindau (VHL) syndrome.

methodsA retrospective analysis was conducted on 80 patients treated at our institution for retinal angiomas due to VHL syndrome from January 2020 to January 2025. Patients were divided into two groups: the intervention group (n = 43) who received laser photocoagulation and the control group (n = 37) who underwent cryotherapy. Visual acuity, angioma characteristics, lesion reduction success, and other clinical parameters were assessed in both groups.

resultsThe laser-treated group demonstrated better visual outcomes than the control group, with significantly lower LogMAR values (P < 0.001). Additionally, fewer recurrences of retinal angiomas occurred in the laser-treated group, with a significantly longer time to recurrence compared to the control group (P = 0.014). The incidence of adverse ocular events, including retinal hemorrhage (P < 0.001), macular edema (P < 0.001), and visual field defects (P < 0.001), was significantly lower in the laser-treated group. Multivariate regression analysis further confirmed that laser photocoagulation (B = 0.997, P < 0.001) was a significant factor for long-term visual outcomes in patients with VHL syndrome, with an odds ratio (OR) of 0.369 (95% CI: 0.200-0.682). Conversely, the mean number of angiomas (B = 2.079, P < 0.001) was a significant factor, with an OR of 7.999 (95% CI: 4.397-14.550), indicating a strong correlation with poorer visual prognosis.

conclusionLaser therapy photocoagulation improves visual outcomes and reduces the risk of complications and recurrence in patients with VHL syndrome. These clinical benefits are important for enhancing the quality of life in affected individuals.

Indexed as

laser treatmentLong-term prognosisretinal angiomasvon hippel-lindau syndrome

Identifiers

PMID41113981
PMCPMC12531280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.