ArticleAmerican journal of cancer research2025
Efficacy of chemotherapy with G-CSF versus plerixafor with G-CSF in autologous stem cell mobilization for lymphoma patients.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
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Abstract
aimsTo compare the efficacy, safety, hematological recovery, immune reconstitution, infection rates, and quality of life (QoL) between two stem cell mobilization regimens - granulocyte colony-stimulating factor (G-CSF) plus chemotherapy versus G-CSF plus plerixafor - in patients with lymphoma undergoing autologous stem cell transplantation (ASCT).
methodsA retrospective cohort study was conducted in 174 lymphoma patients who underwent stem cell transplantation at Shanxi Province Cancer Hospital from 2010 to 2024. Patients were divided into two cohorts: G-CSF plus chemotherapy (n=129) and G-CSF plus plerixafor (n=45). Baseline demographics, CD34+ cell yield and collection efficiency, time to hematopoietic recovery, transfusion requirements, incidence of fever and infections, hematologic abnormalities, immune reconstitution, and patient-reported QoL at 6 months were collected from de-identified medical records and analyzed.
resultsBaseline characteristics were comparable between groups. The G-CSF plus plerixafor group demonstrated significantly higher CD34+ cell counts at the first apheresis, higher total CD34+ cell yields, and a larger proportion of patients achieving ≥ 2 × 10
conclusionMobilization with G-CSF plus plerixafor is associated with higher CD34+ cell yields, faster hematologic and immune recovery, lower complication rates, and better QoL outcomes compared with G-CSF plus chemotherapy in lymphoma patients undergoing ASCT.
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