ArticleAddiction & health2025
Evaluating the Effect of Oxytocin and Zinc Sulphate on Reproductive Indices in Opiate-Addicted Men Receiving Methadone Maintenance Therapy: A Randomized, Double-Masked Clinical Trial.
Article in Addiction & health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Prenatal stress, excitatory-inhibitory imbalance, and ADHD risk: a hypothesis-driven perspective on psilocybin-induced neuroplasticity.Translational psychiatry · 2026Review
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Authors and funding
3 authors.
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Abstract
Background: Despite considerable advances in comprehending the neurobiology of drug addiction, available treatment options remain limited in terms of effectiveness and are often accompanied by adverse side effects that contribute to relapse. Notably, oxytocin administration has demonstrated potential in influencing neurobehavioral changes related to drug abuse. Furthermore, the effect of zinc on male fertility has been established. This study aimed to assess the impact of combining oxytocin with zinc sulfate on reproductive parameters in men addicted to opioids who are undergoing methadone maintenance therapy. Methods: This research followed a double-masked randomized controlled clinical trial design and involved 40 men with opioid dependence receiving methadone treatment. Patients were randomly assigned to one of two groups: a control group receiving a saline nasal spray and a zinc sulfate placebo, and an intervention group receiving 40 international units of oxytocin nasal spray in combination with 220 mg zinc sulfate capsules, daily. Baseline evaluations of testosterone, oxytocin, sperm characteristics, and zinc levels were conducted three days after a 5-10 mg reduction in methadone dosage. Subsequently, a two-week treatment regimen was administered, followed by post-intervention assessments. Findings: The age of participants was comparable in the control and intervention groups. Zinc levels in the control and treatment groups showed no significant difference before the intervention, while a significant increase was seen after the intervention in the treatment group ( Conclusion: According to the results, the combination of oxytocin and zinc supplementation had a positive and significant effect on sperm parameters in opioid-dependent men undergoing methadone treatment.
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