Evidence map›Paper›PMID 41113939›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression.

Brandon Taraku, Jason S Nomi, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Paloma Pfeiffer, Viviane Norris, Shantanu Joshi, Randall Espinoza, Lucina Q Uddin, Katherine L Narr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brandon TarakuAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.ORCID https://orcid.org/0000-0001-7998-1128
Jason S NomiJane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Artemis Zavaliangos-PetropuluAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Noor Al-SharifAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Paloma PfeifferAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Viviane NorrisJane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Shantanu JoshiAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Randall EspinozaJane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Lucina Q UddinJane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Katherine L NarrAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Perturbation of the treatment resistant depression connectome by fast-acting therapiesU01MH110008 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2016 to 2019
$5.5M
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128690 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Katherine L Narr · 2022 to 2026
$2.9M
NIMH NIH HHS R01 MH128690NIMH NIH HHS U01 MH110008
6 · The paper itself

Abstract

Ketamine produces fast-acting antidepressant effects in treatment-resistant depression (TRD). Prior studies have shown altered functional dynamics between brain networks in major depression. We thus sought to determine whether functional brain network dynamics are modulated by ketamine therapy in TRD. Participants with TRD (n = 58, mean age = 40.7 years, female = 48.3%) completed resting-state fMRI scans and clinical assessments (mood and rumination) at baseline and 24 h after receiving 4 ketamine infusions (0.5 mg/kg) over 2 weeks. Healthy controls (HC) (n = 56, mean age = 32.8 years, female = 57.1%) received the same assessments at baseline and after 2 weeks in a subsample without treatment. A co-activation pattern (CAP) analysis identified recurring patterns of brain activity across all subjects using

Indexed as

central executive networkco-activation patternsdynamic functional connectivityketamineruminationsalience networktreatment-resistant depression

Identifiers

PMID41113939
PMCPMC12529346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.