Evidence map›Paper›PMID 41113920›Full record

ReviewInnovation (Cambridge (Mass.))2025

Decoding information stored in DNAs through single-molecule electrical detection platforms.

Li Cheng, Heyilang Cai, Qian Zhan, Yu Jiang, Mingliang Li, Chuancheng Jia, Xuefeng Guo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Precise Probing of Interfaces at the Single-Molecule Scale.Nanomaterials (Basel, Switzerland) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li ChengCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.
Heyilang CaiCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.
Qian ZhanCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.
Yu JiangCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.
Mingliang LiDepartment of Chemistry, The University of Hong Kong, Hong Kong 999077, China.
Chuancheng JiaCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.
Xuefeng GuoCenter of Single-Molecule Sciences, Institute of Modern Optics, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in single-molecule electrical detection techniques have provided a novel microscopic perspective for investigating the properties of single DNA molecules. These state-of-the-art technologies, with their ultra-high resolution at the single-event/single-base level, significantly enhance our understanding of the dynamic properties of single DNA molecules, thus providing valuable guidance for deciphering biological mechanisms, including DNA replication, repair, and transcription. In this review, we highlight the progress achieved through single-molecule electrical detection methodologies, including single-molecule junctions, single-molecule field-effect transistors, and single-molecule nanopores, in studying DNAs at the single-molecule level. Emphasis will be placed on notable discoveries concerning charge-transport properties, conformational dynamics, and sequence-specific analyses within single DNA molecules utilizing single-molecule electrical detection techniques. The application of single-molecule electrical detection techniques in clarifying the structure-function relationship of single DNA molecules is expected to catalyze revolutionary advancements in the fields of bioelectronics, molecular electronics, and nanotechnology.

Indexed as

conformational dynamicsDNA sequencingsingle-molecule field-effect transistorsingle-molecule junctionsingle-molecule nanopore

Identifiers

PMID41113920
PMCPMC12529616

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.