Evidence map›Paper›PMID 41113919›Full record

ArticleInnovation (Cambridge (Mass.))2025

Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells.

Lei Zhang, Moonsook Lee, Xiaoxiao Hao, Xiao Ma, Chuwei Xia, Yiwei Zhao, Joseph Ehlert, Zhongxuan Chi, Bo Jin, Ronald Cutler and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The aging genome exhibits organized vulnerability to somatic mutations.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lei ZhangMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
Moonsook LeeDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiaoxiao HaoDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiao MaMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
Chuwei XiaMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
Yiwei ZhaoMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph EhlertDepartment of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA.
Zhongxuan ChiDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bo JinDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Ronald CutlerDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Alexander Y MaslovDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Albert-László BarabásiDepartment of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA.
Jan H J HoeijmakersDepartment of Molecular Genetics, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands.
Winfried EdelmannDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jan VijgDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiao DongMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Zhengdong Zhang · 2017 to 2026
$24.5M
The role of senescent cells in dysregulating immune responses and pathogen controlP01AI172501 · NIAID · UNIVERSITY OF MINNESOTA · PI STEPHEN C JAMESON · 2024 to 2026
$10.9M
Somatic mosaicism across mouse tissues during different life stagesR35GM159832 · NIGMS · UNIVERSITY OF MINNESOTA · PI Lei Zhang · 2025 to 2026
$847k
NIAID NIH HHS P01 AI172501NIA NIH HHS U19 AG056278NIGMS NIH HHS R35 GM159832
6 · The paper itself

Abstract

Somatic mutations accumulate with age in human tissues. Clonal amplification of some mutations causes cancers and other diseases. However, it is unclear if random mutation accumulation affects cellular function without clonal amplification. We tested this in cell culture, avoiding the limitation that mutation accumulation

Indexed as

agingDNA-mismatch-repair deficiencymutational signaturemutation burdensingle-cell whole-genome sequencing

Identifiers

PMID41113919
PMCPMC12529607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.