ArticleCureus2025
Reliability of Ultrasound Features in Predicting Thyroid Malignancy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Doppler-Scintigraphy Combination with Thyroxine Profiling Enhances Diagnostic Accuracy of Thyroid Lesions: A 144-Patient Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Clinicopathological Significance of Ultrasound Risk Features and the Taller-Than-Wide Sign for Tumor Advancement in Differentiated Thyroid Cancer: A Single-Center Analysis.Cancer management and research · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMETHODOLOGY: Between August 2015 and December 2022, 313 consecutive patients with thyroid nodules presenting to the Surgical Department were screened; out of these, 146 patients underwent surgery
resultsUsing ultrasound diagnostic criteria, 112 patients were classified as positive, and histopathology later confirmed that 84 of these had malignancies. This showed a sensitivity of 95.45%, a specificity of 51%, and a positive predictive value of 75%. Further analysis via the ROC curve showed a high malignancy probability at a point that corresponds to the presence of the 2 ultrasound characteristics, i.e., irregular margin and microcalcification. Specificity and sensitivity at this point are 73.5 and 74.4, respectively.
conclusionThe predefined rule using ≥2 features showed high sensitivity for detecting malignant thyroid nodules, making it useful for screening. The presence of irregular margins and microcalcifications (M + C pair) provided a more balanced sensitivity-specificity trade-off, supporting its use for risk stratification rather than direct surgical decision-making. While these ultrasound criteria show strong diagnostic performance, definitive management decisions should continue to rely on multidisciplinary assessment, integrating cytology, clinical findings, and patient factors. Further prospective validation in larger, unselected cohorts is recommended to refine threshold criteria and confirm generalizability.
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