ArticleFrontiers in molecular biosciences2025
Expression levels of interleukin-17 and interferon-γ in peripheral blood and relationship with thyroid function in patients with Hashimoto's thyroiditis.
Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease.European thyroid journal · 2026Review
- Hashimoto's thyroiditis both promotes and protects against papillary thyroid cancer.Frontiers in endocrinology · 2026Review
- Second-order regulation: IFN-γ suppresses IL-17A-mediated type 3 inflammation.Frontiers in immunology · 2026Article
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5 authors.
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Abstract
Objective: This study aims to unveil the interleukin-17 (IL-17) and interferon-gamma (IFN-γ) levels in the peripheral blood of patients with Hashimoto's thyroiditis (HT) and their association with thyroid function. Methods: We selected 68 HT patients admitted to our hospital and 36 healthy individuals undergoing physical examinations as controls. Clinical data were collected, and serum IL-17 and IFN-γ levels were measured. The Pearson method was used to analyze the correlations between IL-17 and IFN-γ levels and thyroid function parameters. A logistic regression analysis model was employed to evaluate the influencing factors of HT. ROC curves were utilized to assess the diagnostic value of IL-17 and IFN-γ for the occurrence of HT. Results: Serum IL-17 and IFN-γ levels were higher in both HT patients with hypothyroidism and those without hypothyroidism compared to healthy controls ( Conclusion: Serum IL-17 and IFN-γ levels are highly expressed in HT patients, and both are closely related to thyroid function and autoantibody levels. They possessed a certain value for the early diagnosis of HT.
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