ArticleFrontiers in molecular biosciences2025
Clinical association and potential molecular mechanisms of neonatal sepsis and necrotizing enterocolitis.
Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Transcriptional regulatory network analysis uncovers modular gene control and potential key regulators in diabetic cardiomyopathy.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Necrotizing enterocolitis (NEC) is a severe intestinal disease affecting premature infants, with mortality rates of 20%-30%. Clinical studies have shown that neonatal sepsis (NS) is an independent risk factor for NEC; however, the shared molecular mechanisms and diagnostic biomarkers between these two conditions remain poorly understood. This study aims to explore the shared molecular mechanisms underlying the association between NS and NEC and to identify potential diagnostic biomarkers. Methods: This study combines clinical cohort analysis with transcriptomic analysis. First, we enrolled 74 NEC infants and 74 gestational age/birth weight-matched controls from Children's Hospital of Soochow University and quantified the association between NS and NEC using logistic regression analysis. Second, we jointly analyzed transcriptome data from NS (GSE25504) and NEC (GSE46619) datasets to screen for overlapping differentially expressed genes (DEGs) and constructed a protein-protein interaction (PPI) network to identify hub genes. Subsequently, the diagnostic efficacy of core genes was evaluated using independent validation cohorts (GSE297483 and GSE69686). Finally, a transcription factor-mRNA regulatory network was constructed using the TRRUST database to explore the underlying regulatory mechanisms. Results: Clinical association analysis showed a significantly increased risk of NEC in NS infants ( Conclusion: This study suggests that neonatal sepsis may serve as a risk factor for NEC development through shared inflammatory pathways involving
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