SynthesisFrontiers in oral health2025
Malignant transformation rate of oral precancerous disorders to oral cancer: systematic review and meta-analysis of the current evidence.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- PELP1 expression is associated with disease progression in inflammation-driven oral cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Molecular and microenvironmental drivers of malignant transformation from oral potentially malignant disorders to oral squamous cell carcinoma.Frontiers in oncology · 2026Review
- Diagnostic treatment modalities premalignant oral lesions oral cancer progression impact: Comparative study.Bioinformation · 2026Article
- Diagnostic utility of salivary LDH and MMP-9 in differentiating oral cancer from potentially malignant disorders.Bioinformation · 2026Article
- Jing-Si Herbal Tea as a multitargeted complementary therapy: Evidence from preclinical and clinical studies.Tzu chi medical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral potentially malignant disorders (OPMDs) are precancerous conditions that may eventually turn into oral cancer (OC). The aim of this present study was to reassess the data associated with OPMDs and their malignant transformation rate into oral cancer. Methods: A comprehensive search was performed in PubMed, Scopus, Embase, and Web of Science (WoS) to locate studies on OPMDs risk of OC up to July 10, 2025. A summary odds ratio (SOR) was used for the analysis of data. To explore the heterogeneity, subgroup analyses and meta-regression analyses were used. The certainty of evidence was rated using the GRADE protocol. Results: Twenty-nine studies met the inclusion criteria. The meta-analysis showed an elevated risk of OC by overall OPMDs (SOR = 2.5 (95% CI 2.43-2.58). The highest risk of OC in OPMDs were leukoplakia (SOR = 3.35 (95% CI 3.21-3.50), erythroplakia (SOR = 3.3 (95% CI 3.21-3.50), oral epithelial dysplasia (SOR = 1.41 (95% CI 1.20-1.73), and oral submucosa fibrosis (SOR = 2.9 (95% CI 2.70-3.12). Subgroup and meta-regression analyses demonstrated a significant positive association between the development risk of OC with age and duration of follow up. Conclusions: This study suggests a significant association between OPMDs and OC. Age and duration of follow up may modify this association. This study provides insight into the malignant transformation rate to oral cancer to aid researchers, dentists, and clinicians in efficiently controlling this disease in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.