ArticleInternational journal of clinical pediatric dentistry2025
Comparative Evaluation of the Effect of Different Matrix Metalloproteinase Inhibitors on Shear Bond Strength between Composite and Dentin: An
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative evaluation of the resin-dentin interface using different matrix metalloproteinase inhibitors: A confocal laser scanning microscopic study.Journal of conservative dentistry and endodontics · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Matrix metalloproteinases (MMPs) degrade the hybrid layer in dentin bonding, affecting composite restoration longevity. Inhibitors like tetracyclines, chlorhexidine (CHX), and ethylenediaminetetraacetic acid (EDTA) can enhance bond strength. Aim and objective: This study aims to compare the effects of different MMP inhibitors on the SBS between composite and dentin using a universal testing machine. Materials and methods: A total of 64 freshly extracted human premolars, free from cracks or defects, were collected, disinfected in 0.5% chloramine T solution, and stored in distilled water for use within 6 months. These premolars, exhibiting normal anatomy and from patients without orthodontic treatment history, were divided into four groups, including a control group. Teeth were meticulously cleaned, embedded in acrylic resin blocks, and underwent prophylaxis with pumice and water. Composite cylinder build-ups were performed on the specimens, and their SBS was measured. Results: SBS among four different MMP inhibitors, with and without thermocycling, shows a significant difference ( Conclusion: CHX emerged as the most effective MMP inhibitor, with 2% chlorhexidine showing the highest SBS in both thermocycling and nonthermocycling groups, while 17% EDTA showed the lowest. MMP inhibitors, particularly 2% chlorhexidine, help maintain improved dentin bonding durability of adhesive restorations after thermocycling. How to cite this article: Honaje NV, Ninawe N, Anija CK,
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