Aims: The aim of the present study was to evaluate and compare the effect of different pediatric drugs on color stability of Bioflx crowns. Background: Bioflx crowns have emerged as a novel restorative option with the unique property of self-adaptability along with esthetics. Although Bioflx crowns have demonstrated promising clinical performance, their resistance to discoloration remains underexplored. Pediatric liquid medications, often administered to children, are known to cause staining in dental materials. Hence, this study aims to evaluate and compare the effects of different pediatric drugs on the color stability of Bioflx crowns. Materials and methods: A total of 25 Bioflx crowns ( Results: Color variance was least in the Amoxicillin group, followed by Augmentin, Metronidazole, Ibugesic, and I-Fer Kid, the group which showed the highest variance. Conclusion: From the findings of the present study, we can conclude that Bioflx crowns, when immersed in different syrup solutions, showed significant color change in all samples. However, it was not visible to the naked eye. Hence, Bioflx crowns can be considered as a suitable treatment option. Clinical significance: Bioflx crowns are a novel option in pediatric patients in restoring esthetics along with durability and flexibility; hence, maintaining the color stability of these crowns in the oral cavity is crucial for patient acceptance and satisfaction. How to cite this article: Saisree AV, Reshma PK, Dsouza EN,