Evidence map›Paper›PMID 41113757›Full record

ArticlePulmonary circulation2025

Caveolin-1 Is a Central Mediator of Acute Lung Injury in an Animal Model of Sickle Cell Disease.

Clare C Prohaska, Justin R Sysol, Nicole Jones, Robert W Wysocki, Suellen D Oliveira, Richard D Minshall, Roberto F Machado

Abstract read
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In one paragraph

Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clare C ProhaskaDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Internal Medicine Indiana University Indianapolis Indiana USA.
Justin R SysolDepartment of Internal Medicine University of Rochester Rochester New York USA.
Nicole JonesDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Internal Medicine Indiana University Indianapolis Indiana USA.
Robert W WysockiDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Internal Medicine Indiana University Indianapolis Indiana USA.
Suellen D OliveiraDepartment of Anesthesiology University of Illinois College of Medicine at Chicago Chicago Illinois USA.ORCID https://orcid.org/0000-0002-7654-1909
Richard D MinshallDepartment of Pharmacology and Regenerative Medicine University of Illinois College of Medicine at Chicago Chicago Illinois USA.
Roberto F MachadoDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Internal Medicine Indiana University Indianapolis Indiana USA.

Funding

Vascular Targeting Genomic & Genetic Strategies for Acute Chest SyndromeR01HL111656 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Roberto F. Machado · 2013 to 2026
$7.9M
RASA3 is a Candidate Gene in the Pathogenesis of Pulmonary Arterial HypertensionK08HL179459 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Clare Prohaska · 2025 to 2026
$313k
NHLBI NIH HHS K08 HL179459NHLBI NIH HHS L30 HL170349NHLBI NIH HHS R01 HL111656
6 · The paper itself

Abstract

Acute chest syndrome in sickle cell disease (SCD) carries high morbidity and mortality, with up to 15% of patients requiring invasive mechanical ventilation. However, the rates and mechanisms of ventilator-induced lung injury (VILI) in SCD remain poorly understood. We hypothesized individuals with SCD are protected from VILI in a caveolin-1 (Cav-1) dependent manner. SCD mice and control littermates underwent either spontaneous tidal breathing or high tidal volume mechanical ventilation for 4 h (VILI model), or received intratracheal

Indexed as

acute lung injurycaveolin‐1sickle cell disease

Identifiers

PMID41113757
PMCPMC12529879

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.