ArticleFrontiers in microbiology2025
Stage-specific fecal and salivary microbiota signatures for noninvasive detection of colorectal cancer.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Gut microbiota signatures and machine learning-based candidate feature prioritization in advanced colorectal cancer.Archives of microbiology · 2026Article
- Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer.Probiotics and antimicrobial proteins · 2026Review
- Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies.MedComm · 2026Review
- The gut microbiota in colorectal cancer: role in cytokine regulation, intestinal immune barrier dysfunction.Frontiers in oncology · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fecal and salivary microbiota dysbiosis play a crucial role in the pathogenesis of colorectal cancer (CRC). We investigated whether the fecal and salivary microbiota were altered during colorectal tumorigenesis and evaluated their diagnostic performance. Methods: We enrolled 30 metastatic CRC patients, 30 nonmetastatic CRC patients, and 30 healthy controls between October 2023 and September 2024. Fecal and salivary samples were collected for microbial profiling via 16S rDNA sequencing and bioinformatics analysis. Results: Fecal and salivary microbiota composition differed during CRC progression, with salivary microbiota progressively enriched in the gut. In addition, fecal and salivary microbial co-occurrence networks dynamically altered during CRC progression. The natural connectivity of fecal microbial community networks exhibited decreased stability, whereas salivary microbial community networks showed increased stability as CRC progressed. Finally, specific fecal microbial amplicon sequence variants (ASVs) associated with colorectal carcinogenesis enabled precise stage-specific diagnosis of CRC, outperforming salivary ASVs classifiers. Conclusion: This study elucidates stage-specific microbial dynamics in CRC, providing novel insights into clinical diagnostic strategies.
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