Evidence map›Paper›PMID 41113646›Full record

ArticleFrontiers in microbiology2025

Gut viral metagenomics identifies viral signatures and their role in depression.

Xinyu Chen, Jun Wu, Dahua Fan, Peiwen Zhang, Yan Li, Yongkai Cao, Meiqun Cao

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In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu Chen *Graduate School of Guangxi University of Chinese Medicine, Nanning, China.
Jun Wu *Shandong College of Traditional Chinese Medicine, Shandong, China.
Dahua FanShunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Peiwen ZhangDaizhuang Hospital, Jining, China.
Yan LiDepartment of Neurology, Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Yongkai CaoDepartment of Neurology, Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Meiqun CaoDepartment of Neurology, Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The gut microbiome has been implicated in the onset and progression of depression. Yet, the role of the gut virome in depression remains unexplored, and a diagnostic model has not been satisfactorily constructed. Methods: Herein, we analysed the gut virome profiles of 29 patients with depression and 33 healthy controls using bulk metagenome sequencing. Results: A total of 45 differentially abundant viral taxa were identified, among which four, Conclusion: This study identified four distinct viral signatures for depression and proposes novel viral biomarkers for the diagnosis of depression, offering a robust diagnostic approach and new insights into the pathological mechanisms of depression.

Indexed as

depressiondiagnostic signaturesgut viromemetagenomic sequencingviral biomarkers

Identifiers

PMID41113646
PMCPMC12531219

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