ReviewFrontiers in microbiology2025
Probiotics in the prevention and treatment of calcium oxalate kidney stones: mechanisms and therapeutic potential.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The gut-kidney microbiome-oxalate axis in calcium oxalate nephrolithiasis: mechanisms and microbiome-based interventions.Frontiers in cellular and infection microbiology · 2026Pooled it
- The gut-kidney axis in calcium oxalate nephrolithiasis: Nutritional and microbial insights.Northern clinics of Istanbul · 2026Review
- Bioinformatic Analysis of Oxalate-Degrading Enzymes in Probiotics: A Systematic Genome-Scale and Structural Survey.Microorganisms · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Kidney stones, particularly calcium oxalate stones, remain a significant health issue despite advances in treatment techniques. Residual stones that persist after treatment can lead to recurrent stone formation and further complications. The role of gut microbiota, specifically probiotics, in modulating oxalate metabolism has gained increasing attention as a potential therapeutic strategy to reduce residual stones and prevent recurrence. Summary: This paper reviews the potential of probiotics, including recombinant strains, in the treatment of calcium oxalate kidney stones. Probiotics are thought to promote the degradation of oxalate in the gut, thereby reducing its absorption and preventing stone formation. Recent studies have highlighted the beneficial effects of probiotic interventions on gut microbiota composition, oxalate degradation pathways, and calcium oxalate stone formation. Moreover, recombinant probiotics, engineered to enhance oxalate-degrading capabilities, hold promise for improving treatment outcomes. Key messages: This review summarizes recent advancements in the use of probiotics for the prevention and treatment of calcium oxalate kidney stones, with a focus on their role in oxalate degradation and the potential of recombinant probiotics to improve treatment outcomes.
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Registered trials
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