Evidence map›Paper›PMID 41113601›Full record

ArticleRSC advances2025

Synthesis, antidiabetic evaluation, and computational modeling of 3-acetyl-8-ethoxy coumarin derived hydrazones and thiosemicarbazones.

Wajeeha Zareen, Nadeem Ahmed, Ali Muhammad Khan, Suraj N Mali, Nastaran Sadeghian, Naflaa A Aldawsari, Parham Taslimi, Abdullah K Alanazi, Muhammad Tahir, Mussarat Tasleem and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wajeeha ZareenInstitute of Chemical Sciences, Bahauddin Zakariya University 60800 Multan Pakistan zahidshafiq@bzu.edu.pk.
Nadeem AhmedInstitute of Chemical Sciences, Bahauddin Zakariya University 60800 Multan Pakistan zahidshafiq@bzu.edu.pk.ORCID https://orcid.org/0000-0001-6004-0037
Ali Muhammad KhanInstitute of Chemical Sciences, Bahauddin Zakariya University 60800 Multan Pakistan zahidshafiq@bzu.edu.pk.ORCID https://orcid.org/0009-0001-4439-3665
Suraj N MaliSchool of Pharmacy, D.Y. Patil University (Deemed to be University) Sector 7, Nerul Navi Mumbai 400706 India.ORCID https://orcid.org/0000-0003-1995-136X
Nastaran SadeghianDepartment of Biotechnology, Faculty of Science, Bartin University 74110 Bartin Turkiye.
Naflaa A AldawsariChemistry Department, Al-Khurmah University College, Taif University Al-Khurmah 21985 Saudi Arabia.
Parham TaslimiDepartment of Biotechnology, Faculty of Science, Bartin University 74110 Bartin Turkiye.ORCID https://orcid.org/0000-0002-3171-0633
Abdullah K AlanaziDepartment of Chemistry, College of Science, Taif University Taif Saudi Arabia.
Muhammad TahirCollege of Chemistry & Chemical Engineering, Central South University Changsha Hunan 410083 China.
Mussarat TasleemInstitute of Chemical Sciences, Bahauddin Zakariya University 60800 Multan Pakistan zahidshafiq@bzu.edu.pk.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University 60800 Multan Pakistan zahidshafiq@bzu.edu.pk.ORCID https://orcid.org/0000-0003-4088-8297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibiting important enzymes like α-amylase and α-glucosidase is essential for controlling hypoglycemia and its related complications in diabetes mellitus. A series of novel hydrazones and thiosemicarbazones have been synthesized and evaluated for their ability to inhibit enzymes, causing hypoglycemia and diabetes mellitus in the human body. From synthesized compounds, compound 3b from the carbohydrazide series, demonstrated the strongest potency against α-amylase and α-glucosidase, with respective IC

Identifiers

PMID41113601
PMCPMC12530850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.