ArticleFrontiers in pediatrics2025
Laparoscopic Kasai portoenterostomy for biliary atresia: first experience from Central Asia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Objective: Biliary atresia (BA) is a progressive fibro-obliterative disease of the extrahepatic bile ducts. Laparoscopic Kasai portoenterostomy (LKPE) has emerged as a minimally invasive alternative to the open approach. We aimed to evaluate the feasibility, perioperative outcomes, and early prognostic factors of LKPE in a single center. Methods: We conducted a retrospective single-center study. Feasibility, operative metrics (including the learning curve), incidence of cholangitis, native liver survival, and clinical outcomes were assessed using standard statistical methods. Results: Among the 33 patients (14 females, 19 males), the age at surgery was <60 days (12 patients), 60-89 days (13 patients), and >90 days (8 patients). The median operative time was 240 min, showing a declining trend with increasing experience. One conversion (1/33) to open surgery was required due to inadequate hilar visualization. Postoperative cholangitis occurred in 51.5% of cases and was associated with an increased risk of native liver failure (HR = 3.6, Conclusions: LKPE is a feasible and effective surgical option for biliary atresia. Despite its advantages, including enhanced hilar visualization and faster recovery, the high incidence of postoperative cholangitis remains a major challenge that adversely affects native liver survival. Optimizing perioperative management, implementing prophylactic strategies against cholangitis, and expanding pediatric liver transplantation programs in resource-limited settings are essential to improving outcomes. Further prospective studies with long-term follow-up are needed to refine surgical techniques and optimize patient management.
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