ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025
Effect of Heat and Moisture Exchanger vs Heated Humidifier on Ventilator-related Adverse Events in Children: A Pilot Randomized Controlled Trial.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Humidification in the Pediatric Intensive Care Unit: What We Know, What We Need.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Heating and humidification of ventilator gas are essential to ensure optimal ventilator support in critically ill children. Heat and moisture exchangers (HME) offer a simpler and more cost-effective method of humidification compared to active systems like heated humidifiers (HH). However, the efficacy and impact of HME on ventilator-related adverse events (VAEs) in children remain underexplored. This study aims to compare the incidence of VAEs in children managed with HME versus those using a HH during mechanical ventilation. Patients and methods: This open-label randomized controlled trial was conducted in the pediatric intensive care unit (PICU) of a tertiary care hospital in South India from January 2022 to July 2023. Sixty children aged 2-15 years, who were expected to require mechanical ventilation for more than 48 hours, were enrolled. Patients were randomized into two groups after age-based stratification (2-5 years and 6-15 years). The intervention group received humidification via HME, while the control group received a HH. Patients were monitored until discharge, and daily assessments were performed to identify any VAEs for the first 7 days of mechanical ventilation. Results: The primary outcome was the incidence of VAEs, expressed per 1,000 ventilator days. The HME group reported 28.36 VAEs per 1,000 ventilator days, while the HH group had 12.98 VAEs per 1,000 ventilator days. This difference was not statistically significant ( Conclusion: This pilot randomized controlled trial did not find a statistically significant difference in the incidence of VAEs between use of HME and HHs in children. Given its simplicity and cost-effectiveness, HME may be cautiously considered for use in mechanically ventilated pediatric patients aged 2-15 years. How to cite this article: Palanisamy S, Kodakkattil Sreevilasan S, Venkatesh L, Jose D, Gowtham BC, Parameswaran N. Effect of Heat and Moisture Exchanger vs Heated Humidifier on Ventilator-related Adverse Events in Children: A Pilot Randomized Controlled Trial. Indian J Crit Care Med 2025;29(9):746-752.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.