Evidence map›Paper›PMID 41113492›Full record

ArticleWorld journal of diabetes2025

Association between Zhejiang University index and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus.

Xiao-Yan Tao, Tian-Rong Pan, Xing Zhong, Xiao-Yu Pan

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xiao-Yan TaoDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.
Tian-Rong PanDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.
Xing ZhongDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.
Xiao-Yu PanDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Zhejiang University (ZJU) index has been demonstrated to have notable value in predicting metabolic dysfunction-associated steatotic liver disease (MASLD) within Chinese populations. However, the correlation between the ZJU index and MASLD in type 2 diabetes mellitus (T2DM) patients remains to be elucidated.

aimTo investigate the association between the ZJU index and MASLD among patients with T2DM.

methodsThis cross-sectional study was conducted on hospitalised patients diagnosed with T2DM. Anthropometric measurements, laboratory data, and ultrasound results were initially collected from all patients. The ZJU index was subsequently calculated. Regression analysis was then used to explore risk factors affecting MASLD, and the optimal ZJU index cut-off value for diagnosing MASLD was determined using restricted cubic spline analysis. Finally, a new model for predicting MASLD in T2DM patients based on the ZJU index was constructed. This model was based on the risk factors identified by regression analysis, and the area under curve values were calculated. The validity and reliability of the models were then compared with each other.

resultsA total of 688 patients with T2DM were included in this study. A significant positive correlation was identified between the ZJU index and the development of MASLD. Furthermore, the results of the restricted cubic spline analysis showed a non-linear association between ZJU index and MASLD. The ZJU value of 38.87 was identified as the key threshold for diagnosing MASLD. The new predictive model, which was developed by regression analysis, demonstrated a higher diagnostic value for MASLD and exhibited good accuracy in comparison with metabolic indices alone (area under curve = 0.76, 95% confidence interval: 0.72-0.80).

conclusionThe ZJU index has been shown to be linked to the risk of developing MASLD, and the new model constructed has been shown to possess good predictive value.

Indexed as

Body mass indexInsulin resistanceMetabolic dysfunction-associated steatotic liver diseaseType 2 diabetes mellitusZhejiang University index

Identifiers

PMID41113492
PMCPMC12531686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.