Evidence map›Paper›PMID 41113427›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Dynamic Succession of Urokinase-Type Plasminogen Activator in an Oral Squamous Cell Carcinoma Model].

Yuwen Luo, Xuelin Huang, Bomiao Cui, Ning Ji, Ping Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuwen Luo（ 610041） State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.ORCID 0009-0004-8466-322X
Xuelin Huang（ 610041） State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Bomiao Cui（ 610041） State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Ning Ji（ 610041） State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Ping Zhang（ 610041） State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-2344-3336

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically characterizes the temporal changes in urokinase-type plasminogen activator (uPA) over the course of neoplastic progression using a mouse oral squamous cell carcinoma (OSCC) model induced by 4-nitroquinoline-1-oxide (4-NQO). Methods: A total of 65 wild-type C57BL/6 mice of 5 weeks old were randomly assigned to two groups, a 4-NQO group ( Results: After 16 weeks of exposure, 4-NQO-treated mice exhibited significantly lower body mass compared with that of the controls ( Conclusion: This study not only confirmed the uniqueness of the 4-NQO model in OSCC research, but also revealed the changes in uPA during tumor invasion. These findings provide a theoretical foundation for the development of early diagnosis and precision treatment strategies, holding significant potential clinical value and research importance for improving patient prognosis.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsUrokinase-Type Plasminogen Activator4-Nitroquinoline-1-oxideAnimalsDisease Models, AnimalDisease ProgressionMaleMiceMice, Inbred C57BLTongue Neoplasms4-Nitroquinoline-1-oxideUrokinase-Type Plasminogen Activator4-nitroquinoline 1-oxideOral squamous cell carcinomaUrokinase-type plasminogen activator

Identifiers

PMID41113427
PMCPMC12530980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.