Evidence map›Paper›PMID 41113423›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Proteomic Analysis of Bone Serum Protein in Patients With Osteoporosis Accompanied by Obstructive Sleep Apnea Syndrome].

Guohua Guo, Dandong Wei, Jianhong Xiao, Bin Song, Junhua Chen, Qinghua Zhang, Chuanqi Zhu, Die Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Guohua Guo（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.ORCID 0009-0001-6206-4646
Dandong Wei（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.ORCID 0009-0005-1635-4940
Jianhong Xiao（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.
Bin Song（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.
Junhua Chen（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.
Qinghua Zhang（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.
Chuanqi Zhu（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.
Die Liu（ 355000） Department of Respiratory and Critical Care Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan 355000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To analyze the differences in bone serum protein between patients with osteoporosis accompanied by obstructive sleep apnea syndrome (OSAS) and those with osteoporosis only using proteomics. Methods: A total of 80 osteoporosis patients who attended our hospital between June 2022 and June 2024 were enrolled. Based on their polysomnography results, the participants were divided into an OSAS and osteoporosis comorbidity (OSAS-osteoporosis) group ( Results: After propensity score matching, individual characteristics between the groups were well balanced. Mass spectrometry revealed significant differences between the OSAS-osteoporosis and osteoporosis groups. In the PCA score plot, the separation trend of the two groups was not significant. The PLS-DA score plot showed a discernible separation trend, with Conclusion: Significant differences were observed in the metabolic profiles between patients with both OSAS and osteoporosis and those with osteoporosis alone.

Indexed as

Blood ProteinsBone and BonesOsteoporosisProteomicsSleep Apnea, ObstructiveAdultAgedFemaleHumansMaleMiddle AgedPrincipal Component AnalysisBlood ProteinsBone serum protein differenceObstructive sleep apnea syndromeOsteoporosisProteomic technology

Identifiers

PMID41113423
PMCPMC12530981

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