ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Shared Therapeutic Targets of Obesity and Type 2 Diabetes Mellitus and the Intervention Mechanisms of Chinese Herbal Components].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- AFoods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the shared potential targets and molecular mechanisms of obesity and type 2 diabetes mellitus (T2DM) using bioinformatics methods, to validate the expression of core targets through animal experiments, and to analyze the intervention potential of active components of traditional Chinese medicine (TCM). Methods: The obese population datasets (GSE151839 and GSE162653) were obtained from the Gene Expression Omnibus (GEO) database to screen for differentially expressed genes, which were then intersected with T2DM-related targets from the GeneCards database to identify shared targets. A protein-protein interaction (PPI) network was constructed using the STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify enriched biological processes and signaling pathways. The expression of core targets in adipose tissue from patients with obesity and T2DM was validated using the GEO database. A total of 12 specific-pathogen-free (SPF) male Sprague-Dawley (SD) rats, aged 8 weeks and weighing between 180 and 200 g, were randomly assigned to a control group and a model group ( Results: A total of 460 and 796 obesity-related differentially expressed genes were identified in the GSE151839 and GSE162653 datasets, respectively, and 109 shared targets were obtained by intersection with T2DM-related targets. According to PPI network analysis, PTPRC, MMP9, ITGB2, CD86, CCR5, and CCR2 were identified as the core targets. GO and KEGG analysis showed that these targets are mainly enriched in biological processes such as inflammatory response, immune regulation, and cell adhesion. Animal experiments confirmed that the mRNA and protein expression of core targets, including Conclusion: This study reveals the shared molecular mechanisms between obesity and T2DM and shows that core targets, such as PTPRC and MMP9, may promote disease progression by regulating the inflammation-immune network. These findings provide a theoretical basis for the development of targeted therapeutic strategies based on TCM active ingredients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.