Evidence map›Paper›PMID 41113397›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Association of Obesity Phenotypes With Cognitive Impairment and Genetic Stratification Analysis in Older Chinese Adults].

Xin Chen, Haiyu Yan, Qingwen Zhao, Nan Yang, Bin Xu, Jiaqiang Liao, Xia Jiang, Jiayuan Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin Chen/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0008-9696-6798
Haiyu Yan/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Qingwen Zhao/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Nan Yang/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Bin Xu/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-3996-3096
Jiaqiang Liao/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Xia Jiang/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Jiayuan Li/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the association of different obesity phenotypes and their components with the risk of cognitive impairment in older Chinese adults, and to assess the association between obesity and cognitive impairment in different cognition-related genetic backgrounds. Methods: A cross-sectional study based on the West China Health and Aging Cohort was conducted. Logistic regression was applied to estimate the association of obesity phenotypes and components with cognitive impairment in older Chinese adults stratified by Results: A total of 7316 participants were enrolled, of whom 1820 had cognitive impairment. Weight gains were associated with a reduced risk of cognitive impairment (odds ratio [OR] = 0.96, 95% CI, 0.95-0.97). Being overweight with a normal waist-to-hip ratio was a protective factor for cognition (OR = 0.74, 95% CI, 0.61-0.90), whereas the coexistence of elevated waist-to-hip ratio and overweight did not increase the risk of cognitive impairment. Sarcopenia was associated with an elevated risk of cognitive impairment. This association was found in both overweight (OR = 2.03, 95% CI, 1.71-2.41) and non-overweight older adults (OR = 1.86, 95% CI, 1.58-2.20), and was significant across all polygenic risk score strata. Conclusion: Increasing body mass may serve as a key protective factor against cognitive decline in older adults. Having sarcopenia and obesity is associated with an elevated risk of cognitive impairment, independent of genetic susceptibility.

Indexed as

Cognitive DysfunctionObesityAgedApolipoproteins EChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansMaleMiddle AgedOverweightPhenotypeRisk FactorsSarcopeniaWaist-Hip RatioApolipoproteins ECognitive impairmentLean body massObesityPolygenic risk score

Identifiers

PMID41113397
PMCPMC12531020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.