Evidence map›Paper›PMID 41113332›Full record

ArticleOpen forum infectious diseases2025

Discontinuation of Long-acting Injectable Cabotegravir-Rilpivirine in a Large Clinic Cohort.

Katerina A Christopoulos, Xavier Erguera, Janet Grochowski, Matthew Hickey, Elizabeth Imbert, Samantha Dilworth, Ayesha Appa, Chesa Cox, Mary Shiels, Jon Oskarsson and 1 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katerina A ChristopoulosDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-8598-2191
Xavier ErgueraDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7632-0321
Janet GrochowskiDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.
Matthew HickeyDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-8913-1602
Elizabeth ImbertDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-3060-3596
Samantha DilworthDivision of Prevention Science, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-5451-5486
Ayesha AppaDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-4602-5954
Chesa CoxDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-5918-2668
Mary ShielsDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.
Jon OskarssonDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.
Monica GandhiDivision of HIV, ID and Global Medicine, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7025-1994

Funding

Understanding Patient, Provider, and Systems Stakeholder Attitudes and Preferences to Optimize Implementation of Long-Acting Injectable Antiretrovirals and Maximize Clinical and Public Health ImpactR01MH123396 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTOPOULOS, KATERINA A, HICKEY, MATTHEW · 2020 to 2023
$3.2M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
University of California, San Francisco/Kaiser Permanente Northern California Division of Research Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 ProgramK12AR084219 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi, CYNTHIA C HARPER · 2023 to 2026
$3.1M
Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV CareK24AI167805 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katerina A Christopoulos · 2022 to 2026
$963k
Implementation Strategies to Improve Hypertension Treatment in KenyaK23HL162578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Hickey · 2022 to 2026
$944k
NHLBI NIH HHS K23 HL162578NIAID NIH HHS K24 AI167805NIAID NIH HHS R37 AI098472NIAMS NIH HHS K12 AR084219NIMH NIH HHS R01 MH123396
6 · The paper itself

Abstract

Little is known about long-acting injectable cabotegravir-rilpivirine discontinuation outside clinical trials. In a large clinic cohort, 1 in 6 people with HIV discontinued long-acting injectable cabotegravir-rilpivirine over a median of ∼18 months. Injection-related pain was common. Virologic failure and efficacy concerns drove discontinuation for people with HIV with adherence challenges. Most had viral suppression on alternate antiretrovirals post-discontinuation.

Indexed as

discontinuationHIV/AIDSinjectable cabotegravir and rilpivirinelong-acting antiretroviral therapypersistence

Identifiers

PMID41113332
PMCPMC12534727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.