ArticleOpen forum infectious diseases2025
Clinical and Laboratory Features of Hemophagocytic Lymphohistiocytosis in People With Disseminated Histoplasmosis.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome involving pathologic excitation of the immune system. Disseminated histoplasmosis (DH) is a known trigger of HLH. However, the prevalence of HLH in DH is unknown. Limited data exist on risk factors and outcomes. The goals of this study are to determine the prevalence of HLH among participants with DH at a single center, identify risk factors for HLH in this population, and describe the treatment and outcomes of people with DH and HLH. Methods: We retrospectively identified cases of DH at our institution from 2014 to 2022 and reviewed electronic medical records. We used HLH-2004 criteria to identify those with HLH. Results: Among 110 participants with DH, 22 (20%) met criteria for HLH. In the subset who were hospitalized, 24% (22/93) had HLH. Compared to participants without HLH, the HLH cohort was more likely to have serum ferritin above the limit of quantification (LOQ) (>15 000 ng/ml), urine Conclusions: Nearly a quarter of participants with DH admitted to our hospital had HLH. Extreme levels of serum ferritin, urine
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