SynthesisInternational journal of chronic obstructive pulmonary disease2025
Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.
Synthesis in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Low appendicular muscle mass and the risk of COPD development in people with PRISm.ERJ open research · 2026Article
- Detection of House Dust Mite-derived DNA in Human Lung Tumors by Whole-Genome Sequencing.Research square · 2026Article
- Review
- Regenerative therapeutics for chronic obstructive pulmonary disease.Pharmacological reviews · 2026Review
- Scalable discovery and validation of order-specific electronic health record event trajectories for interpretable adverse-outcome risk estimation.Journal of biomedical informatics · 2026Article
- IL-8 drives EMT and malignant progression in chronic obstructive pulmonary disease-associated lung cancer via STAT3 signaling.Cell division · 2026Article
- Targeted Therapy-Induced Interstitial Lung Disease in NSCLC: Mechanisms, Clinical Signatures, and a Precision Medicine Roadmap.Drug design, development and therapy · 2026Review
- Postoperative pulmonary rehabilitation compliance among patients with lung cancer: a cross-sectional survey.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is an important risk factor for the development of, and death from, lung cancer. Methods: We conducted a systematic review and meta-analysis assessing the risk of lung cancer incidence and mortality among adults with a COPD diagnosis in the United States (US) and exploring differences by subgroups. We searched MEDLINE, Embase, and PubMed from inception to July 2024 for observational studies that investigated the association between COPD and lung cancer incidence and mortality risk. We conducted a meta-analysis for overall risk and COPD assessment methods, and a systematic review for analyses within sex, race/ethnicity, smoking status. Results: Twenty observational studies (n=638,610) were included in the systematic review and meta-analysis. US adults with COPD were found to have higher odds of developing (OR, 1.76; [1.53 to 1.99]) and higher hazards of dying (HR, 1.48; [1.06 to 1.89]) from lung cancer compared to those without COPD. Mixed results were observed when stratifying the impact of COPD on lung cancer risk by subgroups (ie, sex, race and ethnicity and smoking status). Generally, the same trend was observed where people in each subgroup with COPD were at higher risk of lung cancer incidence and mortality compared to those in the same subgroups without the disease. Individuals assessed by self-reported COPD and spirometry showed greater incidence risk but not mortality risk. Conclusion: US adults with COPD, including those with a smoking history, are at an increased risk for lung cancer incidence and mortality compared to those without COPD regardless of sex and race and ethnicity.
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Registered trials
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