ArticleVeterinary world2025
Favipiravir as a potent inhibitor of Newcastle disease virus:
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background and Aim: Newcastle disease (ND), caused by velogenic viscerotropic ND virus (VVNDV), remains a major threat to global poultry production, with outbreaks persisting even in vaccinated flocks. No approved antiviral therapy exists for ND, highlighting the urgent need for effective interventions. Favipiravir, a broad-spectrum RNA polymerase inhibitor, has shown promise against several RNA viruses. This study evaluated the toxicity, antiviral efficacy, and molecular mechanisms of favipiravir against VVNDV in an Materials and Methods: Specific pathogen-free embryonated chicken eggs (9-10 days old) were inoculated with VVNDV and treated with graded doses of favipiravir (75-2280 mg/kg/egg biomass). Toxicity was assessed through embryo survival, relative weight, morphological scoring, biochemical markers, and histopathology of liver tissues. Antiviral efficacy was evaluated through embryo survival, growth, hemagglutination (HA) titers, and 50% egg infectious dose (EID Results: Favipiravir displayed dose-dependent toxicity, with the highest dose (2,280 mg/kg) significantly reducing embryo survival (p = 0.027) and inducing hepatic necrosis and elevated alkaline phosphatase and urea levels. In contrast, therapeutic doses of 300 and 600 mg/kg achieved 100% embryo survival, significant weight gains, and complete viral suppression, with undetectable HA activity and EID Conclusion: This study provides the first
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