ArticleIn silico pharmacology2025
Investigation of thiophene derivatives as potential antihypertensive agents: DFT, molecular docking and ADMET studies.
Article in In silico pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite significant advancements in the prevention, detection, and treatment of high blood pressure (BP), hypertension remains a major public health concern. With approximately 1.38 billion individuals affected worldwide, high BP is linked to high mortality and morbidity rates due to stroke, coronary heart disease, congestive heart failure (CHF), and end-stage renal disease, along with a detrimental impact on quality of life. However, medications to completely curtail hypertension are not yet available, but the risk can be reduced through lifestyle modification or a combination of medication and pharmacotherapy. Hence, in this context, we theoretically investigate the potency of the thiophene derivative 5-(4-bromo-5-(methylthio)thiophene-2-yl)- Supplementary Information: The online version contains supplementary material available at 10.1007/s40203-025-00441-2.
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