ArticleTherapeutic advances in musculoskeletal disease2025
Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.
Article in Therapeutic advances in musculoskeletal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Questioning the role of lumbar BMD in vertebral fragility among children with chronic non-bacterial osteomyelitis.Therapeutic advances in musculoskeletal disease · 2026Article
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16 authors.
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Abstract
Background: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory disease characterized by bone pain and sterile bone inflammation. Objectives: This study aimed at describing clinical presentation, laboratory and imaging features, densitometric assessment, and therapeutic approaches in a monocentric CNO cohort. Design: Monocentric retrospective cohort study. Methods: Patients were included in the Chronic non-bActerial osteoMyELitis: A mOnocentric regisTry (CAMELOT) in case of (i) clinical diagnosis of CNO, (ii) the fulfilment of diagnostic/classification criteria, (iii) at least one medical visit at our institution between June 2004 and June 2024, and (iv) a follow-up of at least 3 months. Results: Fifty-one patients were included in the CAMELOT (mean age at onset 11.14 years, 68.6% females). A total of 39.2% of patients presented an autoimmune comorbidity. Bone pain was invariably present; joint involvement was demonstrated in 9.6% of patients. Most subjects (86.3%) had multifocal disease: the median number of bony lesions per patient was 4. Lumbar spine dual-energy X-ray absorptiometry (DXA) was performed in 14 patients (27.4%), showing a reduced bone mineral density (BMD) (-1.14 ± 1.21 Conclusion: The high prevalence of VF observed in the CAMELOT cohort highlights the importance of enlisting CNO in the diagnostic approach to pediatric patients presenting with VF.
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