Evidence map›Paper›PMID 41113074›Full record

ArticleWorld journal of clinical cases2025

Body mass index and its association with clinical outcomes in acute liver failure.

Arunkumar Krishnan, Sameer Khan, Julia Gips, Saleh A Alqahtani, Dhananjay Vaidya, Yi-Si Liu, Ahyoung Kim, Amanda Su, Ahmet Gurakar, James P Hamilton and 1 more

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Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arunkumar KrishnanDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Sameer KhanDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Julia GipsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Saleh A AlqahtaniDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Dhananjay VaidyaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Yi-Si LiuBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, United States.
Ahyoung KimDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Amanda SuDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Ahmet GurakarDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
James P HamiltonDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Tinsay A WoretaDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. tworeta1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute liver failure (ALF) is a life-threatening multisystemic condition with high short-term mortality. With the growing prevalence of obesity and metabolic syndrome, it is important to investigate the clinical implications of high body mass index (BMI) on survival outcomes in ALF.

aimTo explore the impact of overweight and obesity on the clinical outcomes of patients with ALF.

methodsA retrospective observational cohort study was conducted involving patients with ALF admitted to the Johns Hopkins Health System between January 1, 2000 and May 1, 2020. We performed Cox proportional hazards regression to identify outcomes, including the need for liver transplantation (LT) or all-cause mortality.

resultsA total of 196 patients were included, the median age was 43.5 years, 63.3% were female, and 59.7% were of Caucasian ethnicity. Acetaminophen-induced ALF was the most common etiology (45%). The mean BMI was significantly greater among patients who underwent LT or died (29.64 kg/m

conclusionIn this large, retrospective study, with a diverse cohort of United States patients, Overweight and obese were independently associated with an increased risk of all-cause mortality or need for LT. This work highlights the importance of closely monitoring ALF patients who are overweight or obese for adverse complications and measures to improve outcomes in this vulnerable patient population.

Indexed as

Acute liver failureBody mass indexHepatic encephalopathyLiver transplantationMortalityObesityOrgan failureOutcomeSurvival

Identifiers

PMID41113074
PMCPMC12531700

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