ArticleJAC-antimicrobial resistance2025
Prevalence and economic evaluation of acute uncomplicated cystitis in women from Japan: a retrospective cohort study.
Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although Japanese guidelines recommend fluoroquinolones (FQs) and cephalosporins for AUC (acute uncomplicated cystitis) treatment, the emergence of FQ-resistant uropathogens and inappropriate use of antibiotics may lead to treatment failure (TF), and increased healthcare costs. There is a need to understand the epidemiology, treatment patterns, and healthcare cost implications associated with AUC in Japan. Methods: This retrospective cohort study used the Japanese Medical Database Centre database (1 October 2015-30 November 2021). Female patients (≥18 years) had an AUC diagnosis in the same month as ≥1 oral antibiotic prescription claim in the outpatient setting. The population was stratified into cohorts by TF status and history of AUC recurrence prior to index (pre-index recurrence). Baseline demographics were evaluated in the 12-month pre-index period and age standardized prevalence of AUC was calculated. Treatment patterns and AUC-related costs [2022 Japanese Yen (¥)], were reported for the post-index follow-up period. Results: Of 71 476 total patients, 62.46% were aged <50 years. Patients had evidence of TF ( Conclusion: Healthcare providers should consider the cost implications for patients with antibiotic TF or a history of AUC recurrence when selecting antibiotics for empiric treatment in Japan.
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