Evidence map›Paper›PMID 41113065›Full record

ArticleJAC-antimicrobial resistance2025

Emergence of carbapenem-producing enterobacteriaceae (CPE) and other multidrug-resistant gram-negative bacteria in neonates at a tertiary-level NICU in Tanzania: a point prevalence study.

H Naburi, T Sewunet, C Tellapragada, N Nalitolela, M S Wranne, A Joachim, M Kasubi, M Mkony, F Westerlund, C G Giske and 1 more

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Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

H NaburiDepartment of Paediatrics and Child Health, Muhimbili University of Allied Sciences, Dar es Salaam, Tanzania.
T SewunetDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
C TellapragadaDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-0117-5369
N NalitolelaDepartment of Paediatrics and Child Health, Muhimbili University of Allied Sciences, Dar es Salaam, Tanzania.ORCID https://orcid.org/0000-0002-6396-5761
M S WranneDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.
A JoachimDepartment of Microbiology and Immunology, Muhimbili University of Allied Sciences, Dar es Salaam, Tanzania.
M KasubiDepartment of Microbiology and Immunology, Muhimbili University of Allied Sciences, Dar es Salaam, Tanzania.
M MkonyDepartment of Paediatrics and Child Health, Muhimbili University of Allied Sciences, Dar es Salaam, Tanzania.
F WesterlundDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-4767-4868
C G GiskeDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
V NordbergDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Multidrug-resistant (MDR) Gram-negative bacilli pose a significant threat in neonatal care. This study aimed to evaluate the point prevalence and molecular characteristics of intestinal MDR colonization in neonates at Muhimbili National Hospital, Tanzania. Method: We conducted a point prevalence study with faecal samples from 51 neonates born ≥26 weeks gestational age (41% girls, mean 31.6 ± 3.8 weeks) admitted to the neonatal intensive care unit (NICU) at Muhimbili National Hospital on 17 May 2022. The median age at sampling was 8 days (interquartile range 11 days). Samples were cultured on chromogenic agar, and positive colonies underwent antimicrobial susceptibility testing. Whole-genome sequencing and plasmid analysis using Optical DNA Mapping (ODM) were performed on carbapenem-resistant isolates. Results: Among the 51 neonates, 31 (60.7%) were colonized by ESBL-producing Conclusion: A high prevalence of colonization with high-risk clones was observed in neonates, highlighting the urgent need for strengthened MDR-surveillance, infection control, and antibiotic stewardship in the NICU at MNH.

Identifiers

PMID41113065
PMCPMC12528853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.