Evidence map›Paper›PMID 41113055›Full record

ArticleAmerican journal of translational research2025

SERINC4 is dispensable for male fertility and spermatogenesis in mice.

Yuxuan Feng, Yuchen Cui, Xiya Qiu, Mingyuan Bao, Wenxin Gao, Tiantian Wu, Nianchao Zhou, Xiaoyan Huang, Xiaoxue Xi

Abstract read
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Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxuan FengState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Yuchen CuiState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Xiya QiuDepartment of Thyroid and Breast Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Mingyuan BaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Wenxin GaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Tiantian WuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Nianchao ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Xiaoxue XiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTransmembrane proteins are known to play pivotal roles in spermatogenesis and male fertility. Recent transcriptomic analyses have suggested that the serine incorporator 4 (SERINC4), a multi-pass transmembrane protein, is highly expressed in testicular germ cells, yet its physiologic function in male reproduction remains unclear. This study aimed to investigate the

methodsSingle-cell RNA sequencing (scRNA-seq) data were analyzed to determine the expression pattern of

resultsAlthough scRNA-seq analyses revealed high

conclusionsUnder physiologic conditions,

Indexed as

male fertilitySerinc4spermatogenesistestis

Identifiers

PMID41113055
PMCPMC12531537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.