ReviewAmerican journal of translational research2025
The therapeutic effect of norepinephrine alone or in combination with vasopressin on septic shock patients: a meta-analysis.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
objectiveTo evaluate the effects of norepinephrine alone versus norepinephrine in combination with vasopressin on clinical outcomes in patients with septic shock using a Meta-analysis.
methodsRandomized controlled trials (RCTs) comparing norepinephrine monotherapy and combination therapy with vasopressin in septic shock patients were identified through searches of China Knowledge, Wanfang, VIP, and Pubmed databases for studies published between January 1, 2010 and December 31, 2024. Eligible studies were screened based on predefined inclusion and exclusion criteria. Methodological quality was assessed, and data were analyzed using RevMan 5.4 software.
resultsFifteen RCTs involving 1,481 patients were included. Meta-analysis demonstrated that the combination therapy (norepinephrine + vasopressin) significantly improved mean arterial pressure, lactate clearance, heart rate, central venous oxygen saturation, oxygen delivery, and urine output, while reducing blood ammonia and intestinal-type fatty acid-binding protein levels (all
conclusionThe addition of vasopressin to norepinephrine significantly improves hemodynamic parameters in septic shock patients but does not obviously reduce mortality. Further high-quality RCTs are warranted to validate these findings.
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