Evidence map›Paper›PMID 41113036›Full record

ArticleAmerican journal of translational research2025

IgM mediated cefotaxime resistance of

Chenyang Li, Yao Ge, Zhen He, Wen Si, Xin Zhao

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Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chenyang LiOtolaryngology Head and Neck Surgery Center, Xi'an People's Hospital (Xi'an Fourth Hospital) Xi'an 710004, Shaanxi, China.
Yao GeDepartment of Human Anatomy and Histoembryology, School of Basic Medicine Sciences, Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
Zhen HeDepartment of Otorhinolaryngology, Shaanxi Second Provincial People's Hospital Xi'an 710005, Shaanxi, China.
Wen SiDepartment of Otorhinolaryngology, Xi'an No. 1 Hospital Xi'an 710002, Shaanxi, China.
Xin ZhaoDepartment of Otology, Yan'an University Affiliated Hospital Yan'an 716000, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate cefotaxime resistance in

methodsA retrospective cohort study was conducted, enrolling 188 adult AOM patients treated between January 2018 and December 2023.

resultsCefotaxime resistance was significantly positively correlated with hearing loss (r = 0.25, P < 0.001). The hearing loss group exhibited higher prevalence of diabetes history, tympanic effusion, chronic ear disease history, and cefotaxime resistance (P < 0.05). IgM levels were significantly lower in the hearing loss group (P < 0.001) and partially mediated the association between cefotaxime resistance and hearing loss (P = 0.033), accounting for 26.9% of the total effect. Multivariate analysis identified time from symptom onset to admission, tympanic effusion, chronic ear disease history, cefotaxime resistance, and IgM levels as independent predictors of hearing loss (all P < 0.05).

conclusionCefotaxime resistance is associated with an increased risk of hearing loss in adult AOM patients, with IgM partially mediating this relationship. Early identification of resistant strains and IgM monitoring may improve outcomes.

Indexed as

Acute purulent otitis mediacefotaxime resistancehearing lossimmunoglobulinsmediation effectStreptococcus pneumoniae

Identifiers

PMID41113036
PMCPMC12531517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.