ArticleAmerican journal of translational research2025
Comparative effects of enteral nutrition strategies on nutritional indices, inflammatory factors, and clinical outcomes in patients with severe traumatic brain injury.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the effects of different enteral nutrition (EN) strategies on nutritional status, inflammatory factors, immune markers, coagulation function, and clinical outcomes in patients with severe traumatic brain injury (sTBI).
methodsA retrospective analysis was conducted on 121 sTBI patients treated at Yiwu Central Hospital between January 2023 and January 2025. Among them, 58 received early EN alone (control group) and 63 received early EN with probiotics (study group). Pre- and post-treatment comparisons between the two groups included: nutritional indices (total protein [TP], albumin [ALB], and prealbumin [PA]), inflammatory factors (interleukin-6 [IL-6], C-reactive protein [CRP], and tumor necrosis factor-α [TNF-α]), immune-related markers (immunoglobulin A [IgA], IgG, and IgM), coagulation indicators (fibrinogen [Fib] and D-dimer [D-D]) and clinical outcomes (Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores, Glasgow Coma Scale (GCS) scores, incidence of complications, time to first defecation, and time to target feeding volume [TFV]).
resultsFollowing treatment, the study group demonstrated significantly smaller reductions in TP and ALB, greater increases in PA, and more pronounced decreases in IL-6, CRP, and TNF-α (all
conclusionEarly EN combined with probiotics significantly improved nutrition, reduced inflammation, enhanced immune and coagulation function, and improved recovery in sTBI patients.
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