ArticleJournal of biomedical optics2025
Single-distance, phase-only frequency-domain NIRS for vascular oxygenation and tissue metabolism: a Monte Carlo simulation study.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Frequency-domain near-infrared spectroscopy (FD-NIRS) currently enables absolute hemoglobin quantification but requires multidistance measurements of both amplitude attenuation and phase shifts. Notably, existing FD-NIRS approaches have not demonstrated reliable quantification of differential redox-state concentrations of cytochrome c oxidase ( Aim: We aimed to develop a novel optimization-based algorithm for single source-detector (S-D), phase-only FD-NIRS that achieves accurate quantifications of hemoglobin parameters (HbO and Hb) and Approach: Our computational framework implemented both forward modeling and inverse reconstruction. For the modeling, we first defined chromophore concentration sets (HbO, Hb, Results: Respective performances evaluated for the two methods were compared through their concentration recovery accuracy. In either the two- or eight-wavelength configuration, our new algorithm outperformed the conventional method for the S-D separations up to 3 cm for all three chromophores. In particular, Conclusions: These results validate single-separation phase-only FD-NIRS as an accurate method for multichromophore quantification (including
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