Evidence map›Paper›PMID 41112858›Full record

ArticleBiomaterials research2025

Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.

Peng Lu, Tun Wang, Sheng Liao, Zhenyu He, Siyuan Cheng, Tianjian Wang, Zibo Cheng, Yangyang An, Sirui Zhou, Mo Wang and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peng LuDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Tun WangDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Sheng LiaoDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhenyu HeDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Siyuan ChengDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Tianjian WangDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zibo ChengDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Yangyang AnDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Sirui ZhouDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Mo WangDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Qian ZhangState Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430200, China.
Chang ShuDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China.ORCID https://orcid.org/0000-0002-5096-4655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional polymer-based arteriovenous grafts (AVGs) for hemodialysis access suffer from poor long-term patency, high reintervention rates, and susceptibility to infection. In contrast, decellularized tissue-engineered vascular grafts (dTEVGs) demonstrate improved patency, long-term durability, and resistance to infection. However, vascular stenosis and occlusion caused by anastomotic intimal hyperplasia (AIH), as well as vascular stiffening and calcification from excessive perigraft fibrosis (PGF), remain major challenges in the clinical use of dTEVGs for AVGs. M2 macrophage infiltration plays a key role in the biological processes of pro-regeneration and the clinical application of dTEVGs. However, in elastin-rich dTEVGs commonly used clinically, the elastic fiber layers form a barrier to cell infiltration, potentially limiting their biological functions. Therefore, the specific impact of M2 macrophage infiltration on dTEVGs in AVGs remains unclear. Through parallel analysis of human explants and a rat dTEVG-AVG model, we found that M2 macrophage infiltration predominates in dTEVGs, and this infiltration is associated with AIH and PGF. Furthermore, IL-4-loaded poly(lactic-

Identifiers

PMID41112858
PMCPMC12531493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.