Evidence map›Paper›PMID 41112807›Full record

ArticleBiomedical optics express2025

Adaptive fluorescence lifetime imaging with per-pixel signal optimization and flexible scanning.

Siyuan Xie, Gareth O S Williams, Ahsan R Akram, Ahmet T Erdogan, James R Hopgood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siyuan XieCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Gareth O S WilliamsCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Ahsan R AkramCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Ahmet T ErdoganSchool of Engineering, Institute for Integrated Micro and Nano Systems, The University of Edinburgh, Edinburgh, UK.
James R HopgoodSchool of Engineering, Institute for Imaging, Data, and Communications, The University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-3029-2425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in time-resolved fluorescence lifetime imaging microscopy (FLIM) have significantly enhanced biological imaging compared to steady-state techniques alone. The primary goal of modern FLIM is to acquire high-resolution fluorescence lifetime profiles with a high signal-to-noise ratio (SNR) from heterogeneous samples at high speeds, posing challenges in balancing imaging speed, signal strength, and sample integrity. In this study, we present fluorescence lifetime intensity-inverted imaging microscopy (FLI

Identifiers

PMID41112807
PMCPMC12532327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.