Evidence map›Paper›PMID 41112794›Full record

ArticleBiomedical optics express2025

Using the latent diffusion model to enhance time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow.

Faraneh Fathi, Rabeya Tus Sadia, Mehrana Mohtasebi, Paul Mos, Claudio Bruschini, Edoardo Charbon, Lei Chen, Jin Chen, Guoqiang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Faraneh FathiDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, 40506, USA.ORCID https://orcid.org/0000-0001-8061-6304
Rabeya Tus SadiaDepartment of Computer Science, University of Kentucky, Lexington, Kentucky, 40506, USA.
Mehrana MohtasebiBioptics Technology LLC, Advanced Science & Technology Commercialization Center (ASTeCC), Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0002-4689-990X
Paul MosSchool of Engineering, Ecole polytechnique fédérale de Lausanne, Neuchâtel 2002, Switzerland.
Claudio BruschiniSchool of Engineering, Ecole polytechnique fédérale de Lausanne, Neuchâtel 2002, Switzerland.ORCID https://orcid.org/0000-0002-6636-6596
Edoardo CharbonSchool of Engineering, Ecole polytechnique fédérale de Lausanne, Neuchâtel 2002, Switzerland.ORCID https://orcid.org/0000-0002-0620-3365
Lei ChenDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, 40506, USA.
Jin ChenDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
Guoqiang YuDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, 40506, USA.

Funding

Noninvasive Noncontact High-Density Optical Imaging of Neonatal Intraventricular HemorrhageR01HD101508 · NICHD · UNIVERSITY OF KENTUCKY · PI YU, GUOQIANG · 2020 to 2024
$2.7M
Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brainR42MH135825 · NIMH · BIOPTICSTECHNOLOGY, LLC · PI YU, GUOQIANG · 2023 to 2025
$2.1M
Development of a Wearable Fluorescence Imaging Device for IntraoperativeIdentification of Brain TumorsR42CA243600 · NCI · BIOPTICSTECHNOLOGY, LLC · PI YU, GUOQIANG · 2023 to 2025
$2.0M
Perioperative Diffuse Optical Imaging of Tissue Blood Flow and Oxygenation for Optimization of Mastectomy Skin Flap ViabilityR01EB028792 · NIBIB · UNIVERSITY OF KENTUCKY · PI YU, GUOQIANG · 2020 to 2024
$1.9M
High-density optical tomography of cerebral blood flow and metabolism in small animalsR41NS122722 · NINDS · BIOPTICSTECHNOLOGY, LLC · PI YU, GUOQIANG · 2021 to 2022
$688k
A Multiscale Multimodal Diffuse Optical Device for Early Detection of Preclinical Alzheimer’s DiseaseR21HD091118 · NICHD · UNIVERSITY OF KENTUCKY · PI YU, GUOQIANG · 2018 to 2019
$568k
Non-contact Diffuse Optical Assessment of Pressure Ulcer and TherapyR21AR062356 · NIAMS · UNIVERSITY OF KENTUCKY · PI YU, GUOQIANG · 2012 to 2013
$350k
NCI NIH HHS R42 CA243600NIAMS NIH HHS R21 AR062356NIBIB NIH HHS R01 EB028792NICHD NIH HHS R01 HD101508NICHD NIH HHS R21 HD091118NIMH NIH HHS R42 MH135825NINDS NIH HHS R41 NS122722
6 · The paper itself

Abstract

Continuous monitoring of cerebral blood flow (CBF) with high spatiotemporal resolution and depth sensitivity is essential for accurate diagnosis and effective management of neurological disorders. Although conventional laser speckle contrast imaging (LSCI) enables widefield, high-resolution CBF mapping, its limited penetration depth and signal integration across all tissue layers hinder depth-resolved imaging. To address these limitations, we developed an advanced time-resolved LSCI (TR-LSCI) system that employs picosecond-pulsed laser illumination and a customized SPAD512

Identifiers

PMID41112794
PMCPMC12532319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.