Evidence map›Paper›PMID 41112782›Full record

ArticleBiomedical optics express2025

Label-free multiphoton microscopy of human skin: longitudinal studies capturing cell dynamics.

Alexander Vallmitjana, Amanda Durkin, Alexander Dvornikov, Belén Torrado, Kristen M Kelly, Jessica Shiu, Anand K Ganesan, Mihaela Balu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander VallmitjanaBeckman Laser Institute, University of California, Irvin, CA 92617, USA.ORCID https://orcid.org/0000-0002-7149-9385
Amanda DurkinBeckman Laser Institute, University of California, Irvin, CA 92617, USA.
Alexander DvornikovBeckman Laser Institute, University of California, Irvin, CA 92617, USA.
Belén TorradoBeckman Laser Institute, University of California, Irvin, CA 92617, USA.ORCID https://orcid.org/0000-0002-0679-3422
Kristen M KellyBeckman Laser Institute, University of California, Irvin, CA 92617, USA.
Jessica ShiuBeckman Laser Institute, University of California, Irvin, CA 92617, USA.
Anand K GanesanBeckman Laser Institute, University of California, Irvin, CA 92617, USA.
Mihaela BaluBeckman Laser Institute, University of California, Irvin, CA 92617, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imagingR01EB026705 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mihaela Balu, Anand K Ganesan · 2018 to 2026
$4.2M
Fast, large area, multiphoton exoscope (FLAME) for improving early detection of melanomaR01CA259019 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALU, MIHAELA, KELLY, KRISTEN M · 2022 to 2025
$3.1M
In vivo label free optical imaging of immune cells in human skinR21AR082648 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALU, MIHAELA, GANESAN, ANAND K · 2023 to 2024
$374k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA259019NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R21 AR082648NIBIB NIH HHS R01 EB026705
6 · The paper itself

Abstract

This study presents recent advances in an imaging platform developed by our lab, the fast large area multiphoton exoscope (FLAME), a microscope designed for clinical skin imaging. Its dual-scanning modality enables reliable, cellular-scale imaging of the same skin locations over extended time periods across areas up to 1 cm

Identifiers

PMID41112782
PMCPMC12532326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.