ArticleBiomedical optics express2025
Light transport in the human spine for optical bone density assessment: Monte Carlo modeling and validation.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Frequency-Specific Transcranial Photobiomodulation Elicits Complementary Glial Mechanisms for Neurovascular Protection and Amyloid Clearance in Alzheimer Disease.Cyborg and bionic systems (Washington, D.C.) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal disorders are an increasing global health concern, especially in aging populations. Conventional diagnostic methods rely on ionizing radiation, limiting their suitability for portable or frequent assessments. Near-infrared spectroscopy provides a promising non-invasive alternative for evaluating spinal properties, particularly bone mineral density (BMD). This study explores the feasibility of optical monitoring through Monte Carlo simulations based on the Visible Chinese Human dataset. Photon migration at 660, 808, and 980 nm was quantified and visualized, with 808 nm demonstrating the largest penetration depth of up to 3.5 cm in the spinal region. The optimal source-detector separation was identified as 3.4-3.8 cm. In vivo measurements in human subjects further validated the reliability of the simulation results. The pilot experiment revealed a significant correlation between detected signal and BMD, with lower BMD associated with relatively higher light intensity. These findings highlight the potential of optical techniques for spinal BMD assessment and support the development of portable monitoring systems.
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Registered trials
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