ArticleFrontiers in nutrition2025
The association between iron deficiency and muscle mass/strength in patients undergoing maintenance hemodialysis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health.Nutrients · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: Patients with end-stage renal disease (ESRD) are at high risk of losing muscle mass and strength, especially those undergoing maintenance hemodialysis (MHD). Iron deficiency (ID) may exacerbate this condition, however, its relationship with muscle mass/strength remains largely unclear. Therefore, we aim to investigate the association between ID status and muscle mass/strength in Chinese patients undergoing hemodialysis. Methods: This cross-sectional study was conducted at a hemodialysis center in southwest China from September to December 2022. Iron status was assessed by plasma ferritin and transferrin saturation (TSAT). Muscle strength was measured by handgrip strength (HGS), and muscle mass was evaluated using the appendicular skeletal muscle index (ASMI). Linear regression and subgroup analysis with interaction terms were performed to explore the associations. Results: 269 participants on MHD aged 18-85 years were included, 21.9% (59/269) had ID. Participants with ID exhibited significantly lower handgrip strength, but similar ASMI, compared to those without ID (grip strength: 21.6 ± 8.7 vs. 24.3 ± 8.9, ASMI: 6.5 ± 1.2 vs. 6.5 ± 1.0). After adjusting for potential covariates, ID was negatively associated with handgrip strength ( Conclusion: These findings demonstrate that ID is significantly associated with reduced muscle strength in patients on MHD in southwest China. Additionally, ID was significantly associated with muscle mass only in overweight participants. These results provide strong support for the importance of individualized iron-repletion strategies to preserve muscle health in patients on MHD, particularly those who are overweight, although further verification in prospective studies is needed.
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