Evidence map›Paper›PMID 41112725›Full record

ArticleMedComm2025

Cordycepin Targets HRD1 to Promote Cancer Cell PD-L1 Ubiquitin-Proteasome Degradation and Increase Antitumor Immunity.

Xiangxin Geng, Minchen Cai, Hongmei Hu, Mengting Xu, Qing Zhang, Hanchen Xu, Dianping Yu, Hongwei Zhang, Hanchi Xu, Linyang Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intracellular PD-L1: Functions, Regulation, and Therapeutic Implications.International journal of biological sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiangxin GengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Minchen CaiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Hongmei HuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Mengting XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Qing ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Hanchen XuInstitute of Digestive Diseases Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China.
Dianping YuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Hongwei ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Hanchi XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Linyang LiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Mengmeng GuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Shize XieDepartment of Phytochemistry School of Pharmacy Second Military Medical University Shanghai China.
Qun WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.
Weidong ZhangDepartment of Phytochemistry School of Pharmacy Second Military Medical University Shanghai China.
Sanhong LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.ORCID https://orcid.org/0000-0002-8695-0343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint blockade has become an effective strategy for inhibiting tumor growth, especially immune checkpoint inhibitors that target the programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, which have shown significant effects in tumor immunotherapy. In this study, we found that naturally sourced

Indexed as

colorectal cancer (CRC)cordycepin (COR)Cordyceps militaris extract (CME)HMG‐CoA reductase degradation protein 1 (HRD1)programmed death‐ligand 1 (PD‐L1)

Identifiers

PMID41112725
PMCPMC12531455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.