ReviewJB & JS open access
Local Antibiotic Delivery Systems and Their Applications in Orthopaedic Surgery.
Review in JB & JS open access. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of topical vancomycin in preventing surgical site infection following fracture surgery : a systematic review and meta-analysis.Bone & joint open · 2026Pooled it
- Vancomycin elution from gamma-irradiated cancellous bone allograft: an in vitro study linking soaking concentration to clinically relevant antimicrobial thresholds.Cell and tissue banking · 2026Article
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Local Antibiotic-Loadable Carriers for the Treatment of Chronic Osteomyelitis: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Antibiotic-Loaded PLA Composites for Local Prevention of Implant-Associated Infections: Comparative Evaluation Against Reference Strains and Clinical Isolates.Antibiotics (Basel, Switzerland) · 2026Article
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- Right forearm wound and soft tissue abscess complicated with sepsis due to Streptococcus suis: a case report.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
» Local antibiotic delivery systems are critical in managing periprosthetic and fracture-related infections, providing high local antibiotic concentrations without systemic side effects. Polymethyl methacrylate (PMMA), the first material to be mixed with antibiotics to perform local antibiotic therapy in orthopaedic history, offers reliable antibiotic delivery above the Minimum Inhibitory Concentration (MIC), typically used with heat-stable antibiotics such as vancomycin, tobramycin, and gentamicin. However, excessive antibiotics can weaken the cement, especially in total joint arthroplasty (TJA). When used for bone defects, a second surgery is often required to replace PMMA with bone grafts. » Calcium sulfate (CaSO
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.