ArticleFrontiers in public health2025
Updates on exposure estimation for the Québec cohort of chrysotile miners and millers: implications for risk assessment and threshold hypothesis.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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Abstract
The McGill University cohort of Québec chrysotile miners and millers (total of 11,379 members) has been a major determinant of risk assessment. The U. S. EPA and some other meta-analyses omit this cohort, the largest ever exposed to high concentrations of chrysotile. Preliminary analyses using new data showed average cumulative exposures in the full cohort of 528.5 f/cc-years (95% CI 510.3, 546.7) or 979 f/cc-years (95% CI 945, 1,013), depending on the regression equation used for the modeling. The lowest estimated exposure level observed for any mesothelioma case with diagnostic certainty was 68 f/cc-years. We confirmed that the estimation of potency factor for Québec chrysotile should not be expected to differ significantly from Darnton's estimation for non-textile chrysotile (R
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