Evidence map›Paper›PMID 41112622›Full record

ArticleWorld journal of psychiatry2025

Enhancing schizophrenia treatment efficacy: The combined impact of Yueju pill and olanzapine through quercetin target modulation.

Dian-Ming Zhu, Ying Lu, Xu-Dong Xiao, Yang Sun, Gang Tao, Bin Long, Jing Zhao

Abstract read
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In one paragraph

Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dian-Ming ZhuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China.
Ying LuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China.
Xu-Dong XiaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China.
Yang SunShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China.
Gang TaoZhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine, Zhenjiang Hospital of Traditional Chinese Medicine, Zhenjiang 212008, Jiangsu Province, China.
Bin LongShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China.
Jing ZhaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai 201108, China. maggy-1978@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia is a complex psychiatric disorder with significant functional impairment. Although olanzapine is effective in treating positive symptoms, its efficacy against negative symptoms and cognitive deficits is limited. Yueju pill, a traditional Chinese herbal formula, has shown potential in improving these domains, but its mechanisms remain largely unexplored.

aimTo evaluate the therapeutic efficacy and underlying mechanisms of Yueju pill combined with olanzapine in treating schizophrenia.

methodsNinety-seven patients with schizophrenia were randomly assigned to an intervention group (

resultsThe intervention group demonstrated a significantly higher overall efficacy rate (93.75%) compared to the control group (73.47%,

conclusionYueju pill, when combined with olanzapine, significantly improves clinical outcomes in schizophrenia patients, with safety comparable to olanzapine alone.

Indexed as

Brain-derived neurotrophic factorCognitive functionDopamine pathwayNetwork pharmacologyOlanzapineQuercetinSchizophreniaYueju pill

Identifiers

PMID41112622
PMCPMC12531966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.